![]() Use this section to learn more about the key technologies and tools used by Clario and. Click the 'Create an Account' button to get started. Relying on automated measurements from ECG devices for patient inclusion and treatment (dis)continuation decisions poses a potential risk to patients participating in oncology studies.Ĭore lab ECG algorithm False negative Oncology trials QRS QTcF. Find prospects by the technologies they use. Among the ECGs with a centrally measured QRS > 110 or 120 ms, 7.9% and 7.3% respectively had a device reported QRS value ≤ 110 ms or ≤ 120 ms. Automated measurements also failed to detect QRS prolongation, though to a lesser extent than failures to detect QTc prolongation. With almost 50 years of experience, Clario has mastered. Automated QTcF measurements failed to detect a QTcF increase > 60 ms for 53.9% of the ECGs identified by the core lab. Clario is committed to innovating the future of clinical trials through technology and having a positive impact on global healthcare. ![]() Among the ECGs with a centrally measured QTcF > 500 ms, 55.8% had a device reported value ≤ 500 ms. Clario is a leading healthcare research and technology company that generates the richest clinical evidence in the industry for our pharmaceutical. Among the ECGs with a centralized QTcF value > 450 or > 470 ms, 39.5% and 47.8% respectively had a device reported QTcF value ≤ 450 ms or ≤ 470 ms. ![]() The mean differences between the core lab and the automated algorithm QTcF and QRS measurements were + 1.8 ± 16.0 ms and - 1.0 ± 8.8 ms, respectively. Using a dataset of over 260,000 ECGs collected in clinical oncology studies, we investigated the mean difference and the rate of false negative results between the digital ECG machine QTc and QRS measurements compared to those obtained by a centralized ECG core lab. Clario is part of the Healthcare Software industry, and located in Pennsylvania, United States. Sites participating in clinical trials may not have the expertise and infrastructure to accurately measure cardiac intervals on 12-lead ECGs and rely heavily on the automated ECG device generated results for clinical decision-making.
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